60 wins & 208 nominations including Winner for Best Performance by a Female Actor in a Motion Picture - Musical or Comedy (Demi Moore) at the 82nd Annual Golden Globes and 2004 Cannes Film Festival Winner - Best Screenplay.

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Have you ever dreamt of a better version of yourself? You, only better in every way. You should try this new product, it’s called The Substance. It changed my life. With The Substance, you can generate another you: younger, more beautiful, more perfect. You just have to share time – one week for one, one week for the other. A perfect balance of seven days each... Easy right? If you respect the balance... What could possibly go wrong?

"Audaciously gross, wickedly clever, and possibly Demi Moore's finest hour, The Substance is a gasp-inducing feat from writer-director Coralie Fargeat." - Critics Consensus, Rotten Tomatoes

"If Moore’s extraordinary, best-of-career performance doesn’t kick off a full Demi-aissance, there is no God - this riff on The Picture of Dorian Gray goes ballistic in the best possible way." - Rolling Stone